Car Sick
I don't get car sick every time. However within about the first 5 minutes of a trip I will know if it will be a problem. The upside, If i do not get sick the first time I will not get sick ever. Downside. If I do get sick I will get sick every time.

Must sit in front.
See #1. Sitting in the front is the only thing that will easy car sickness.

Noisy
I don't ride quiet. If there's music I will sing along, if there is no music, I will talk. Your only hope is that I fall asleep. See #4

Sleep anywhere
I can sleep, and have slept, just about anywhere.

Know your rest stops.
I have diabetes and something about the motion of a vehicle makes me need to stop. When I say I need to "go" you have about 10 minutes to find a place to stop or it will get ugly really fast.

Have a destination
I do not go for the sake of going. Tell me where we are going and go there. I don't go for rides and if your plan is to just ride around and "look at stuff" then do not take me.

Know how to get there.
For some reason, (which I refuse to take the blame for) people I travel with get lost a lot.