Cellphone
Have to be able to be reached if needed

Laptop
or other means of internet access.

A Good Book
There's never anything good on a hotel tv!

My pillow
Hotel pillows suck, they're always too soft.

Clothing for any occaision
You never know what might happen...

Shoes!
again, you never know what might happen :)

Meds
Its hard to replace a Rx when you're out of town